3D Attention M-net for Short-axis Left Ventricular Myocardium Segmentation in Mice MR cardiac Images

• Published in: 2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC) Vol. 2021; pp. 3353 - 3357
• Main Authors: Huang, Luojie, Jin, Andrew, Wei, Jinchi, Tipre, Dnyanesh, Liu, Chin-Fu, Weiss, Robert G., Ardekani, Siamak
• Format: Conference Proceeding Journal Article
• Language: English
• Published: United States IEEE 01.11.2021
• Subjects: Analytical models; Animals; Attention; Heart Ventricles - diagnostic imaging; Image segmentation; Logic gates; Magnetic Resonance Imaging; Mice; Myocardium; Reproducibility of Results; Rodents; Three-dimensional displays
• ISSN: 2694-0604
• DOI: 10.1109/EMBC46164.2021.9630335

Small rodent cardiac magnetic resonance imaging (MRI) plays an important role in preclinical models of cardiac disease. Accurate myocardial boundaries delineation is crucial to most morphological and functional analysis in rodent cardiac MRIs. However, rodent cardiac MRIs, due to animal's small cardiac volume and high heart rate, are usually acquired with sub-optimal resolution and low signal-to-noise ratio (SNR). These rodent cardiac MRIs can also suffer from signal loss due to the intra-voxel dephasing. These factors make automatic myocardial segmentation challenging. Manual contouring could be applied to label myocardial boundaries but it is usually laborious, time consuming, and not systematically objective. In this study, we present a deep learning approach based on 3D attention M-net to perform automatic segmentation of left ventricular myocardium. In the deep learning architecture, we use dual spatial-channel attention gates between encoder and decoder along with multi-scale feature fusion path after decoder. Attention gates enable networks to focus on relevant spatial information and channel features to improve segmentation performance. A distance derived loss term, besides general dice loss and binary cross entropy loss, was also introduced to our hybrid loss functions to refine segmentation contours. The proposed model outperforms other generic models, like U-Net and FCN, in major segmentation metrics including the dice score (0.9072), Jaccard index (0.8307) and Hausdorff distance (3.1754 pixels), which are comparable to the results achieved by state-of-the-art models on human cardiac ACDC17 datasets.Clinical relevance Small rodent cardiac MRI is routinely used to probe the effect of individual genes or groups of genes on the etiology of a large number of cardiovascular diseases. An automatic myocardium segmentation algorithm specifically designed for these data can enhance accuracy and reproducibility of cardiac structure and function analysis.