Polyacetylene Carboxylic Acids from Mitrephora celebica

• Published in: Journal of natural products (Washington, D.C.) Vol. 64; no. 10; pp. 1348 - 1349
• Main Authors: ZGODA, Joanna R., FREYER, Alan J., KILLMER, Lew B., PORTER, John R.
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 01.10.2001; Amer Chemical Soc; American Society of Pharmacognosy
• Subjects: Acetylene - analogs & derivatives; Acetylene - chemistry; Acetylene - isolation & purification; Acetylene - pharmacology; Alkynes; Annonaceae - chemistry; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - isolation & purification; Anti-Bacterial Agents - pharmacology; Biological and medical sciences; Carboxylic Acids - chemistry; Carboxylic Acids - isolation & purification; Carboxylic Acids - pharmacology; Chemistry, Medicinal; Diynes; Drug Evaluation, Preclinical; Drug Resistance, Microbial; General pharmacology; Indonesia; Life Sciences & Biomedicine; Magnetic Resonance Spectroscopy; Medical sciences; Methicillin - pharmacology; Molecular Structure; Mycobacterium smegmatis; Mycobacterium smegmatis - drug effects; Pharmacognosy. Homeopathy. Health food; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Plant Sciences; Plant Stems - chemistry; Plants, Medicinal - chemistry; Polymers - chemistry; Polymers - isolation & purification; Polymers - pharmacology; Polyynes; Science & Technology; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Staphylococcus aureus; Staphylococcus aureus - drug effects; Acetylenic compound; Bark; Mycobacterium smegmatis; Stem; Meticillin; Medicinal plant; Carboxylic acid; Dicotyledones; Angiospermae; Bacteria; Micrococcales; Micrococcaceae; Annonaceae; Staphylococcus aureus; Aliphatic compound; Pharmacognosy; In vitro; Biological activity; Enynic compound; Resistance; Mycobacteriales; Plant origin; Mycobacteriaceae; Isolation; Actinomycetes; Spermatophyta; Antibacterial agent; Diynic compound; Structural analysis
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np0102509

A new polyacetylene carboxylic acid, 13(E),17-octadecadiene-9,11-diynoic acid (13,14-dihydrooropheic acid, 1), and the known 17-octadecene-9,11,13-triynoic acid (oropheic acid, 2) were isolated from the stem bark of Mitrephora celebica through bioassay-guided fractionation. Both compounds demonstrated significant activity against methicillin-resistant Staphylococcus aureus and Mycobacterium smegmatis.