Coupling X-Ray and optical tomography systems for in vivo examination of small animals

For the purpose of the co-registration of fluorescence optical signal and X-rays measurements, a multimodality tomographer has been developed in our laboratory. Such a system brings the possibility to get, on the same bench, in vivo both anatomical and functional information. Moreover, the informati...

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Published in2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society Vol. 2007; pp. 3335 - 3338
Main Authors da Silva, A., Bordy, T., Debourdeau, M., Dinten, J.-M., Peltie, P., Rizo, P.
Format Conference Proceeding Journal Article
LanguageEnglish
Published United States IEEE 01.01.2007
Subjects
Animals
Biomedical optical imaging
Equipment Design
Equipment Failure Analysis
Fluorescence
Image Enhancement - instrumentation
Imaging phantoms
In vivo
Laboratories
Mice
Microscopy, Fluorescence - instrumentation
Microscopy, Fluorescence - veterinary
Optical coupling
Reproducibility of Results
Sensitivity and Specificity
Testing
Tomography
Tomography, Optical - instrumentation
Tomography, Optical - veterinary
Tomography, X-Ray Computed - instrumentation
Tomography, X-Ray Computed - veterinary
Whole Body Imaging - instrumentation
Whole Body Imaging - veterinary
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Summary:For the purpose of the co-registration of fluorescence optical signal and X-rays measurements, a multimodality tomographer has been developed in our laboratory. Such a system brings the possibility to get, on the same bench, in vivo both anatomical and functional information. Moreover, the information on the morphology of the animal can be used as a regularization factor in order to get the reconstructions of the biodistribution of fluorochromes more accurate and to reduce the computation time. A study on homogeneous phantoms was conducted to evaluate the feasibility, to test the linearity and the reproducibility, and to fix the parameters for the co-registration. More cumbersome phantoms (sacrificed mice) have then been considered and the test experiments were reproduced. Finally, results of a study conducted in vivo on mice bearing tumors in the lungs, tagged with different types of optical probes, are presented.
ISBN:9781424407873
1424407877
ISSN:1094-687X
1557-170X
1558-4615
DOI:10.1109/IEMBS.2007.4353044