Altered cortical causality after remifentanil administration in healthy volunteers: A novel approach for pharmaco-EEG

Alterations in cortical causality information flow induced by remifentanil infusion in healthy volunteers was investigated in a placebo-controlled double-blind cross-over study. For each of the 21 enrolled male subjects, 2.5 minutes of resting electroencephalography (EEG) data were collected before...

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Published in2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society Vol. 2014; pp. 4290 - 4293
Main Authors Khodayari-Rostamabad, Ahmad, Graversen, Carina, Olesen, Soren S., Malver, Lasse P., Kurita, Geana P., Sjogren, Per, Christrup, Lona L., Drewes, Asbjorn M.
Format Conference Proceeding Journal Article
LanguageEnglish
Published United States IEEE 01.01.2014
Subjects
Adult
Analgesics, Opioid - administration & dosage
Bones
Brain - drug effects
Brain - physiology
Cognition - drug effects
Cross-Over Studies
Double-Blind Method
Electrodes
Electroencephalography
Electroencephalography - methods
Healthy Volunteers
Heating
Humans
Indexes
Male
Pain
Pain Perception - drug effects
Piperidines - administration & dosage
Reaction Time
Robustness
Young Adult
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Summary:Alterations in cortical causality information flow induced by remifentanil infusion in healthy volunteers was investigated in a placebo-controlled double-blind cross-over study. For each of the 21 enrolled male subjects, 2.5 minutes of resting electroencephalography (EEG) data were collected before and after infusion of remifentanil and placebo. Additionally, to assess cognitive function and analgesic effect, continuous reaction time (CRT) and bone pressure and heat pain were assessed, respectively. The causality information was extracted from the EEG by phase slope index (PSI). Among the features being reproducible between the two baseline recordings, several PSI features were altered by remifentanil administration in comparison to placebo. Furthermore, several of the PSI features altered by remifentanil were correlated to changes in both CRT and pain scores. The results indicate that remifentanil administration influence the information flow between several brain areas. Hence, the EEG causality approach offers the potential to assist in deciphering the cortical effects of remifentanil administration.
ISSN:1094-687X
1557-170X
1558-4615
DOI:10.1109/EMBC.2014.6944573