Impedance changes according to the degree of atopi dermatitis in mice

• Published in: 2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society Vol. 2011; pp. 2526 - 2529
• Main Authors: Kim, S. C., Park, H. S., Kim, S. M., Park, J. K.
• Format: Conference Proceeding Journal Article
• Language: English
• Published: United States IEEE 01.01.2011
• Subjects: Animals; Capacitance; Dermatitis, Atopic - physiopathology; Electric Impedance; Frequency measurement; Impedance; Impedance measurement; Instruments; Male; Mice; Skin
• ISBN: 9781424441211; 1424441218
• ISSN: 1094-687X; 1557-170X; 1558-4615
• DOI: 10.1109/IEMBS.2011.6090699

Variations in electrical impedance over frequency might be used to distinguish the degree of atopic dermatitis (AD), even if the mechanisms of the skin barrier impairment due to AD are still unknown. We observed the skin bioimpedance of normal mice and of abnormal mice having atopic with instrument measuring electrical impedance. Electrical impedance was measured from 20Hz to 1MHz at many frequencies and normalized with several indices such as IMP, PIX, IMIX, RIX, and et al. to reduce variation in subjects. The results showed the high relationship between subjective score and indices, especially, the capacitance change and impedance ratio, abs(Z 1kHz )/abs(Z 10kHz ). These results indicate electrical impedance may be a promising clinical diagnostic tool to monitor prognosis of skin care for atopic dermatitis. Using developed software application we easily acquired complex impedance data from the instrument and got the analysis results for very kinds of frequency. This may be useful in various bioimpedance studies such as skin cancer assessment or body composition analysis, or etc.