Intrinsic CO2 Permeability of Cell Membranes and Potential Biological Relevance of CO2 Channels

The past dozen years has seen a series of papers that come to the conclusion that CO2 passes through certain aquaporins and Rhesus proteins. The past three years has seen another series of papers that come to the conclusion that protein channels could not make a meaningful contribution to overall CO...

Full description

Saved in:
Bibliographic Details
Published inChemphyschem Vol. 12; no. 5; pp. 1017 - 1019
Main Authors Boron, Walter F., Endeward, Volker, Gros, Gerolf, Musa-Aziz, Raif, Pohl, Peter
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 04.04.2011
WILEY‐VCH Verlag
Subjects
Aquaporin 1 - chemistry
Aquaporin 1 - metabolism
Biological Transport
carbon dioxide
Carbon Dioxide - chemistry
Carbon Dioxide - metabolism
Cell Membrane Permeability
Erythrocytes - metabolism
gas permeation
Humans
membranes
phospholipids
transport
Online AccessGet full text

Cover

More Information
Summary:The past dozen years has seen a series of papers that come to the conclusion that CO2 passes through certain aquaporins and Rhesus proteins. The past three years has seen another series of papers that come to the conclusion that protein channels could not make a meaningful contribution to overall CO2 membrane permeability because of a combination of: 1) a high CO2 permeability of membrane lipids and 2) large unstirred layers, which would render their CO2 resistance much higher than that of a biological membrane. Is this also true for a membrane crowded with proteins? This comment summarizes the current status of the debate.
Bibliography:ArticleID:CPHC201100034
istex:8E70F1C3555B988B4B4AE945156C9ECAF04EAE1A
ark:/67375/WNG-2ZG369RR-P
Comment to A. Missner and P. Pohl, ChemPhysChem 2009, 10, 1405-1414. The authors are listed in alphabetical order. The three groups of Boron, Musa-Aziz, of Pohl and of Endeward, Gros have contributed equally to this letter.
2009
The authors are listed in alphabetical order. The three groups of Boron, Musa‐Aziz, of Pohl and of Endeward, Gros have contributed equally to this letter.
Comment to A. Missner and P. Pohl, ChemPhysChem
,
10
1405–1414.
SourceType-Other Sources-1
content type line 63
ObjectType-Correspondence-1
ObjectType-Commentary-2
ISSN:1439-4235
1439-7641
DOI:10.1002/cphc.201100034