The characterization of synthetic by-products by B/E linked scanning and high-resolution thermospray mass spectrometry

Characterization of unknown synthetic by-products from a test synthesis of the experimental inhibitor of HIV-1 reverse transcriptase, BI-RG-587, is presented. Seven impurities were separated and characterized by thermospray liquid chromatography/mass spectrometry using low-resolution, high-resolutio...

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Bibliographic Details
Published inBiological mass spectrometry Vol. 20; no. 5; p. 268
Main Authors Dinallo, R M, Davidson, W C, Hansen, G E
Format Journal Article
LanguageEnglish
Published England 01.05.1991
Subjects
Antiviral Agents - chemical synthesis
HIV-1 - enzymology
Humans
Mass Spectrometry - methods
Nevirapine
Pyridines - chemical synthesis
Reverse Transcriptase Inhibitors
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Summary:Characterization of unknown synthetic by-products from a test synthesis of the experimental inhibitor of HIV-1 reverse transcriptase, BI-RG-587, is presented. Seven impurities were separated and characterized by thermospray liquid chromatography/mass spectrometry using low-resolution, high-resolution, and B/E linked scanning methods. The high-resolution mass measurements which were obtained were accurate to within 10 ppm of structures proposed for synthetic by-products present at the 0.1% level. Linked scans produced daughter ion spectra for each impurity to further aid in the characterization.
ISSN:1052-9306
DOI:10.1002/bms.1200200506