The effect of heparin and of acid-citrate-dextrose solution on screen filtration pressure of blood in experimental hypotension

Anticoagulation with heparin may not always adequately protect an ischaemic vascular bed. A screen filtration device has been employed to study the in vitro actions of acid-citrate-dextrose (ACD) and heparin on blood from the dog in haemorrhagic shock. With both anticoagulants, blood obtained during...

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Bibliographic Details
Published inBritish journal of surgery Vol. 62; no. 9; p. 713
Main Authors Pardy, B J, Dudley, H A
Format Journal Article
LanguageEnglish
Published England 01.09.1975
Subjects
Animals
Anticoagulants - pharmacology
Blood Coagulation - drug effects
Blood Pressure - drug effects
Citrates - pharmacology
Dogs
Filtration
Glucose - pharmacology
Heparin - pharmacology
Hydrogen-Ion Concentration
Hypotension - blood
In Vitro Techniques
Oxygen - blood
Shock, Hemorrhagic - blood
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Summary:Anticoagulation with heparin may not always adequately protect an ischaemic vascular bed. A screen filtration device has been employed to study the in vitro actions of acid-citrate-dextrose (ACD) and heparin on blood from the dog in haemorrhagic shock. With both anticoagulants, blood obtained during shock caused greater filter obstruction than blood taken before shock. However, the increased obstruction was nearly four times greater with heparinized blood than with acid-citrate-dextrose blood. These findings suggest that the anticoagulant action of heparin may be markedly diminished in low blood flow states.
ISSN:0007-1323
1365-2168
DOI:10.1002/bjs.1800620910