Effectiveness of photodynamic therapy with topical 5-aminolevulinic acid and intense pulsed light in Chinese acne vulgaris patients

• Published in: Photodermatology, photoimmunology & photomedicine Vol. 29; no. 2; pp. 90 - 96
• Main Authors: Mei, Xingyu, Shi, Weimin, Piao, Yinglan
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.04.2013
• Subjects: 5-aminolevulinic acid; acne; Acne Vulgaris - therapy; Adult; Aminolevulinic Acid - adverse effects; Aminolevulinic Acid - therapeutic use; Asian Continental Ancestry Group; China; Female; Follow-Up Studies; Humans; intense PULSED light; Intense Pulsed Light Therapy - adverse effects; Male; Photochemotherapy - adverse effects; photodynamic therapy; Photosensitizing Agents - adverse effects; Photosensitizing Agents - therapeutic use; Treatment Outcome; Young Adult; China
• ISSN: 0905-4383; 1600-0781
• DOI: 10.1111/phpp.12031

Summary Background The success rates of conventional treatments to acne vulgaris are limited because of intolerance and resistance. Photodynamic therapy with topical 5‐aminolevulinic acid (ALA) and red light has been introduced. However, the side effects especially pigmentation are common. Objective To study the efficacy and safety of ALA‐photodynamic therapy (PDT) with 420–950 nm intense pulsed light (IPL) in Chinese patients with acne vulgaris. Methods Forty‐one patients with moderate to severe facial acne were randomly assigned to ALA‐IPL‐PDT group and IPL group. Ten percent topical ALA was applied to patients in the ALA‐IPL‐PDT group, while placeboes were applied to patients in the IPL group. After 1 h occlusion, all patients were illuminated with 420–950 nm IPL. The patients in both groups had four treatment sessions with 1‐week intervals. One week after each treatment and 4, 8, and 12 weeks after four sessions, acne lesion counts and adverse events were observed. Results Twelve weeks after treatments, mean reductions of global lesion counts of ALA‐IPL‐PDT group and IPL group were 75.2% and 51.0%, respectively. Mean reductions of inflammatory and non‐inflammatory lesion counts in ALA‐IPL‐PDT group were (83.6 ± 4.1)% and (57.5 ± 6.8)%, respectively. No severe adverse events were observed. Conclusion ALA‐IPL‐PDT is an effective treatment for moderate to severe acne vulgaris, and side effects are mild and reversible.