Effectiveness of photodynamic therapy with topical 5-aminolevulinic acid and intense pulsed light in Chinese acne vulgaris patients
Summary Background The success rates of conventional treatments to acne vulgaris are limited because of intolerance and resistance. Photodynamic therapy with topical 5‐aminolevulinic acid (ALA) and red light has been introduced. However, the side effects especially pigmentation are common. Objective...
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Published in | Photodermatology, photoimmunology & photomedicine Vol. 29; no. 2; pp. 90 - 96 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
England
Blackwell Publishing Ltd
01.04.2013
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Subjects | |
Online Access | Get full text |
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Summary: | Summary
Background
The success rates of conventional treatments to acne vulgaris are limited because of intolerance and resistance. Photodynamic therapy with topical 5‐aminolevulinic acid (ALA) and red light has been introduced. However, the side effects especially pigmentation are common.
Objective
To study the efficacy and safety of ALA‐photodynamic therapy (PDT) with 420–950 nm intense pulsed light (IPL) in Chinese patients with acne vulgaris.
Methods
Forty‐one patients with moderate to severe facial acne were randomly assigned to ALA‐IPL‐PDT group and IPL group. Ten percent topical ALA was applied to patients in the ALA‐IPL‐PDT group, while placeboes were applied to patients in the IPL group. After 1 h occlusion, all patients were illuminated with 420–950 nm IPL. The patients in both groups had four treatment sessions with 1‐week intervals. One week after each treatment and 4, 8, and 12 weeks after four sessions, acne lesion counts and adverse events were observed.
Results
Twelve weeks after treatments, mean reductions of global lesion counts of ALA‐IPL‐PDT group and IPL group were 75.2% and 51.0%, respectively. Mean reductions of inflammatory and non‐inflammatory lesion counts in ALA‐IPL‐PDT group were (83.6 ± 4.1)% and (57.5 ± 6.8)%, respectively. No severe adverse events were observed.
Conclusion
ALA‐IPL‐PDT is an effective treatment for moderate to severe acne vulgaris, and side effects are mild and reversible. |
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Bibliography: | ArticleID:PHPP12031 istex:C0928843C94140C6EFAE58C075A1EA934B20BFA1 ark:/67375/WNG-4JNPPRQQ-C ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-News-1 ObjectType-Feature-3 content type line 23 |
ISSN: | 0905-4383 1600-0781 |
DOI: | 10.1111/phpp.12031 |