Synthesis of the Trypanosoma cruzi LPPG Heptasaccharyl myo-Inositol

Synthesis of the heptasaccharyl myo-inositol found in Trypanosorna cruzi lipopeptidophosphoglycan was accomplished using a convergent assembly of three building blocks. The target compound is the first complete 2-aminoethyl phosphonic acid substituted glycan related to the glycosylphosphatidylinosit...

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Published inJournal of the American Chemical Society Vol. 128; no. 10; pp. 3414 - 3419
Main Authors HEDEROS, Markus, KONRADSSON, Peter
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 15.03.2006
Amer Chemical Soc
Subjects
Animals
Carbohydrate Sequence
Chemistry
Chemistry, Multidisciplinary
Glycolipids - chemical synthesis
Glycolipids - chemistry
Glycosylation
Inositol Phosphates - chemical synthesis
Inositol Phosphates - chemistry
Molecular Sequence Data
Physical Sciences
Polysaccharides - chemical synthesis
Polysaccharides - chemistry
Science & Technology
TECHNOLOGY
TEKNIKVETENSKAP
Trypanosoma cruzi - chemistry
Trypanosoma cruzi - metabolism
CELLS
IMMUNE-SYSTEM
D-GALACTOSE
GLYCAN
GLYCOINOSITOLPHOSPHOLIPIDS
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Summary:Synthesis of the heptasaccharyl myo-inositol found in Trypanosorna cruzi lipopeptidophosphoglycan was accomplished using a convergent assembly of three building blocks. The target compound is the first complete 2-aminoethyl phosphonic acid substituted glycan related to the glycosylphosphatidylinositol anchor family to be synthesized. The order of assembly enables synthesis of phosphoinositol oligosaccharicles related to other glycosylinositolphospholipids in Tr. cruzi, the protozoan parasite causing Chagas' disease, which is endemic in South America.
Bibliography:istex:A31A3F48D8C289449A8AB0C8CA5933922876E4C5
ark:/67375/TPS-619P5X8C-Z
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0002-7863
1520-5126
1520-5126
DOI:10.1021/ja057339b