Trapping of Cell-Laden Hyaluronic Acid-Acrylamide Hydrogel Droplets using Bulk Acoustic Waves

In this paper an acoustofluidic system to trap hydrogel droplets is shown. The presented trapping method is label-free, biocompatible and operated in non-contact mode. The results show that the droplets can be trapped at flow rates up to 76 µL/min which corresponds to an average flow speed of 3.2 mm...

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Bibliographic Details
Published in2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems & Eurosensors XXXIII (TRANSDUCERS & EUROSENSORS XXXIII) pp. 2352 - 2355
Main Authors Fornell, Anna, Johannesson, Carl, Searle, Sean S., Happstadius, Axel, Nilsson, Johan, Tenje, Maria
Format Conference Proceeding
LanguageEnglish
Published IEEE 01.06.2019
Subjects
Acoustics
Acoustofluidics
droplet microfluidics
Fluorescence
Glass
hydrogels
Microfluidics
Oils
particle manipulation
Piezoelectric transducers
System-on-chip
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Summary:In this paper an acoustofluidic system to trap hydrogel droplets is shown. The presented trapping method is label-free, biocompatible and operated in non-contact mode. The results show that the droplets can be trapped at flow rates up to 76 µL/min which corresponds to an average flow speed of 3.2 mm/s. Moreover, it is shown that the droplets can be trapped for several hours, thus allowing for studies of the encapsulated cells over time. An application of the system is shown by performing on-chip cell nuclei staining.
ISSN:2167-0021
DOI:10.1109/TRANSDUCERS.2019.8808393