A Cytotoxic Sesquiterpene Alkaloid from the South China Sea Gorgonian Subergorgia suberosa

A new sesquiterpene alkaloid, 6-(9'-purine-6',8'-diolyl)-2 beta-suberosanone (1), together with three known sesquiterpenes, suberosenol A (2), subergorgic acid (3), and subergorgiol (4), was isolated from the EtOH/ CH2Cl2 extracts of the South China Sea gorgonian Subergorgia suberosa....

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Bibliographic Details
Published inJournal of natural products (Washington, D.C.) Vol. 68; no. 8; pp. 1288 - 1289
Main Authors QI, Shu-Hua, ZHANG, Si, LI, Xiang, LI, Qing-Xin
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 01.08.2005
Amer Chemical Soc
American Society of Pharmacognosy
Subjects
Alkaloids - chemistry
Alkaloids - isolation & purification
Alkaloids - pharmacology
Animals
Anthozoa - chemistry
Antineoplastic Agents - chemistry
Antineoplastic Agents - isolation & purification
Antineoplastic Agents - pharmacology
Biological and medical sciences
Chemistry, Medicinal
Drug Screening Assays, Antitumor
General pharmacology
Humans
Inhibitory Concentration 50
Life Sciences & Biomedicine
Medical sciences
Molecular Structure
Pharmacognosy. Homeopathy. Health food
Pharmacology & Pharmacy
Pharmacology. Drug treatments
Plant Sciences
Science & Technology
Sesquiterpenes - chemistry
Sesquiterpenes - isolation & purification
Sesquiterpenes - pharmacology
Tumor Cells, Cultured
South China Sea
CARDIOTOXIN
Antineoplastic agent
Purine derivatives
Nitrogen heterocycle
Saturated compound
Cytotoxicity
Marine environment
Coelenterata
Alkaloid
Sesquiterpenes
Cnidaria
Bicyclic compound
Mammary gland
Tumor cell
Human
Terpenoid
Pharmacognosy
Animal origin
Tricyclic compound
Ketone
In vitro
Biological activity
Cell line
Isolation
Invertebrata
Structural analysis
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Summary:A new sesquiterpene alkaloid, 6-(9'-purine-6',8'-diolyl)-2 beta-suberosanone (1), together with three known sesquiterpenes, suberosenol A (2), subergorgic acid (3), and subergorgiol (4), was isolated from the EtOH/ CH2Cl2 extracts of the South China Sea gorgonian Subergorgia suberosa. The structure of 1 was determined through spectroscopic methods. Compound 1 showed moderate cytotoxicity against the human breast carcinoma MDA-MB-231 cell line with an IC50 of 8.87 mu g/mL.
Bibliography:istex:C734D0AB0B27CD72EC3225262355089A00FAAA5B
ark:/67375/TPS-BV0L3KJN-S
ISSN:0163-3864
1520-6025
DOI:10.1021/np050105l