A meta-analysis of genome-wide linkage scans for hypertension: The National Heart, Lung and Blood Institute Family Blood Pressure Program

• Published in: American journal of hypertension Vol. 16; no. 2; pp. 144 - 147
• Main Authors: Province, Michael A., Kardia, Sharon L.R., Ranade, Koustubh, Rao, Dabeeru C., Thiel, Bonnie A., Cooper, Richard S., Risch, Neil, Turner, Stephen T., Cox, David R., Hunt, Steven C., Weder, Alan B., Boerwinkle, Eric
• Format: Journal Article
• Language: English
• Published: New York, NY Oxford University Press 01.02.2003; Elsevier Science
• Subjects: Arterial hypertension. Arterial hypotension; Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Chromosome Mapping; Chromosomes, Human, Pair 2 - genetics; Clinical manifestations. Epidemiology. Investigative techniques. Etiology; Databases as Topic; Genetic Linkage; genome scan; Genome, Human; Government Programs; Humans; hypertension; Hypertension - genetics; Lod Score; Medical sciences; Meta-analysis; National Institutes of Health (U.S.); United States; United States; Human; Hypertension; Linkage; Race; genome scan; Cardiovascular disease; Arterial pressure; Genome; Genetic determinism; Comparative study; Metaanalysis; Meta-analysis
• ISSN: 0895-7061; 1879-1905
• DOI: 10.1016/S0895-7061(02)03248-X

Background: Four multicenter Networks (GenNet, GENOA, HyperGEN, SAPPHIRe) form the National Heart, Lung and Blood Institute Family Blood Pressure Program (FBPP), to search for hypertension/blood pressure (BP) genes. The networks used different family designs and targeted multiple ethnic groups, using standardized protocols and definitions. Linkage genome scans were done on samples within each network (N = 6245 relatives). Methods: The evidence was synthesized using meta-analysis. Results: Combining ethnic groups, no region reached LOD >2, but several small peaks were identified, including chromosome 2p where two other recent reports find hypertension linkage. Conclusions: No regions show uniformly large effects on BP/hypertension in all populations. Am J Hypertens 2003;16:144–147 @ 2003 American Journal of Hypertension, Ltd.