New Sesquiterpenes from Litsea verticillata
Seven new sesquiterpenes, named litseagermacrane (1), 7-epi-eudesm-4(15)-ene-1a,6a-diol (2), 5-epieudesm-4(15)-ene-1b,6b-diol (4), litseahumulanes A (6) and B (7), and litseachromolaevanes A (11) and B (12), as well as the known compounds 7-epi-eudesm-4(15)-ene-1b,6b-diol (3), eudesm-4(15)-ene-1b,6a...
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Published in | Journal of natural products (Washington, D.C.) Vol. 66; no. 5; pp. 609 - 615 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
WASHINGTON
American Chemical Society
01.05.2003
Amer Chemical Soc American Society of Pharmacognosy |
Subjects | |
Online Access | Get full text |
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Summary: | Seven new sesquiterpenes, named litseagermacrane (1), 7-epi-eudesm-4(15)-ene-1a,6a-diol (2), 5-epieudesm-4(15)-ene-1b,6b-diol (4), litseahumulanes A (6) and B (7), and litseachromolaevanes A (11) and B (12), as well as the known compounds 7-epi-eudesm-4(15)-ene-1b,6b-diol (3), eudesm-4(15)-ene-1b,6a-diol (5), octahydro-4-hydroxy-3a-methyl-7-methylene-a-(1-methylethyl)-1H-indene-1-methanol (8), 10-hydroxyl-15-oxo-a-cadinol (9), and aphanamol II (10), were isolated from an anti-HIV fraction of the leaves and twigs of Litsea verticillata Hance (Figure 1). Isolates 1, 4, and 12 were found to inhibit HIV-1 replication in a green fluorescent protein (GFP)-based reporter cell line (HOG.R5) with IC50 values of 6.5 (27.5), 17.4 (73.1), and 28.0 (119.7) mg/mL (mM), respectively. The structures of these isolates were determined by spectral data including 1D and 2D NMR spectra. Compound 11 was confirmed by X-ray crystallographic analysis. |
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Bibliography: | istex:8713B6E7D093809282412F855237EACA5B92C56E ark:/67375/TPS-54B2J37H-5 |
ISSN: | 0163-3864 1520-6025 |
DOI: | 10.1021/np020508a |