Ananosic Acids B and C, Two New 18(13→12)-abeo-Lanostane Triterpenoids from Kadsura ananosma

• Published in: Journal of natural products (Washington, D.C.) Vol. 67; no. 5; pp. 875 - 877
• Main Authors: CHEN, Ye-Gao, HAI, Li-Na, LIAO, Xin-Rong, QIN, Guo-Wei, XIE, Yu-Yuan, HALAWEISH, Fathi
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 01.05.2004; Amer Chemical Soc; American Society of Pharmacognosy
• Subjects: Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - isolation & purification; Antineoplastic Agents, Phytogenic - pharmacology; Biological and medical sciences; Chemistry, Medicinal; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal - chemistry; Drugs, Chinese Herbal - isolation & purification; Drugs, Chinese Herbal - pharmacology; General pharmacology; HeLa Cells; Humans; Inhibitory Concentration 50; Kadsura - chemistry; Lanosterol - analogs & derivatives; Lanosterol - chemistry; Lanosterol - isolation & purification; Lanosterol - pharmacology; Life Sciences & Biomedicine; Medical sciences; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Pharmacognosy. Homeopathy. Health food; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Plant Sciences; Plant Stems - chemistry; Plants, Medicinal - chemistry; Science & Technology; Triterpenes - chemistry; Triterpenes - isolation & purification; Triterpenes - pharmacology; Tumor Cells, Cultured; Asia; China; LIGNANS; Antineoplastic agent; Steroid; Endemic species; Leukemia; Cytotoxicity; Uterine cervix; Stem; Medicinal plant; Carboxylic acid; Dicotyledones; Angiospermae; Vinylic compound; Secondary alcohol; Schisandraceae; Acylate; Tumor cell; Human; Lanostane derivatives; Terpenoid; Pharmacognosy; Ketone; In vitro; Hela cell line; Biological activity; Cell line; Plant origin; Triterpene; Isolation; Spermatophyta; Structural analysis
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np0340302

Two new 18(13-->12)-abeo-lanostane triterpenoid acids, ananosic acids B (1) and C (2), were isolated from the stems of Kadsura anaosma. Their structures were elucidated by spectral studies and chemical transformation. Compounds 1 and 2 were evaluated for cytotoxicity using CCRF-CEM leukemia cells and HeLa cells.