Chemical Constituents from Drypetes littoralis

• Published in: Journal of natural products (Washington, D.C.) Vol. 64; no. 6; pp. 707 - 709
• Main Authors: LIN, Mei-Tsu, CHEN, Lih-Chun, CHEN, Chien-Kuang, CHEN LIU, Karin C. S., LEE, Shoei-Sheng
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 01.06.2001; Amer Chemical Soc; American Society of Pharmacognosy
• Subjects: Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - isolation & purification; Antineoplastic Agents, Phytogenic - pharmacology; Biological and medical sciences; Chemistry, Medicinal; Diterpenes - chemistry; Diterpenes - isolation & purification; Euphorbiaceae - chemistry; General pharmacology; Life Sciences & Biomedicine; Mass Spectrometry; Medical sciences; Pharmacognosy. Homeopathy. Health food; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Plant Extracts - chemistry; Plant Sciences; Plants, Medicinal - chemistry; Science & Technology; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Taiwan; Taiwan; DITERPENES; XANTHONES; Terpenoid; Pharmacognosy; Tricyclic compound; Oxygen heterocycle; Stem; Medicinal plant; Dicotyledones; Angiospermae; Plant origin; Diterpene; Phenols; Euphorbiaceae; Isolation; Spermatophyta; Aromatic compound; Structural analysis
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np0005964

Chemical investigation of Drypetes littoralis yielded three new tricyclic diterpenes, drypetenones A, B, and C (1-3), and one new xanthone (4). Spectral analyses and chemical correlations established the structures as 10S-12-hydroxy-11-methoxy-13-methylpodocarpa-1,5,8,11,13-pentaene-3,7-dione, (1), 10S-12-hydroxy-11-methoxy-13-methylpodocarpa 10S-12-hydroxy-6,11dimethoxy-13-methylpodocarpa-1,5,8, 11,13-pentaene-3,7-dione (3), and 1-hydroxy-7-hydroxymethyl-6-methoxyxanthone (4). Complete C-13 NMR assignment of boehmenan D (5) is also made.