A New Macrocyclic Trichothecene, 12,13-Deoxyroridin E, Produced by the Marine-Derived Fungus Myrothecium roridum Collected in Palau

• Published in: Journal of natural products (Washington, D.C.) Vol. 64; no. 3; pp. 396 - 398
• Main Authors: NAMIKOSHI, Michio, AKANO, Kyoko, MEGURO, Shiori, KASUGA, Isao, MINE, Yuji, TAKAHASHI, Takenori, KOBAYASHI, Hisayoshi
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 01.03.2001; Amer Chemical Soc; American Society of Pharmacognosy
• Subjects: Animals; Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents; Antineoplastic Agents - chemistry; Antineoplastic Agents - isolation & purification; Antineoplastic Agents - pharmacology; Applied microbiology; Ascomycota - chemistry; Biological and medical sciences; Chemistry, Medicinal; Chemotherapic agents; Fundamental and applied biological sciences. Psychology; HL-60 Cells; Humans; Leukemia L1210; Life Sciences & Biomedicine; Magnetic Resonance Spectroscopy; Marine Toxins - chemistry; Marine Toxins - isolation & purification; Marine Toxins - pharmacology; Microbiology; Molecular Structure; Morphology, structure, chemical composition; Mycology; Mycotoxins - chemistry; Mycotoxins - isolation & purification; Mycotoxins - pharmacology; Pharmacology & Pharmacy; Plant Sciences; Science & Technology; Trichothecenes - chemistry; Trichothecenes - isolation & purification; Trichothecenes - pharmacology; Tumor Cells, Cultured; Pacific Ocean Islands; MICROORGANISMS; NATURAL-PRODUCTS; BIOACTIVE METABOLITES; Antineoplastic agent; Leukemia; Mycotoxin; Cytotoxicity; Oxygen heterocycle; Macrocycle; Fungi; Marine environment; Sesquiterpenes; Vinylic compound; Conjugated dienic compound; Fungi Imperfecti; Secondary alcohol; Tumor cell; Thallophyta; Terpenoid; Rodentia; Lactone; Tetracyclic compound; In vitro; Trichothecene; Biological activity; HL60 cell line; L1210 cell line; Toxin; Vertebrata; Mammalia; Cell line; Microbial origin; Mouse; Animal; Isolation; Myrothecium roridum; Structural analysis
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np000443g

A new macrocyclic trichothecene, 12,13-deoxyroridin E (I), and three known compounds, roridin E (2), verrucarin A (3), and verrucarin J (4), were obtained as cytotoxic components from the marine-derived fungus Myrothecium roridum, isolated in Palau. 12,13-Deoxyroridin E is the second example of a macrocyclic trichothecene possessing a double bond at C-12-C-13 and was about 80-fold less cytotoxic than roridin E, the epoxide variant.