Three New Phenolic Compounds from a Manipulated Plant Cell Culture, Mirabilis jalapa
Bioassay-guided fractionation of an organic extract of the cell mass from a manipulated plant cell culture of Mirabilis jalapa led to the isolation and subsequent identification of three new phenolic compounds, 1, 2, and 3. The isoflavone 1 and dehydrorotenoid 2 were identified as the principal anti...
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| Published in | Journal of natural products (Washington, D.C.) Vol. 64; no. 3; pp. 313 - 317 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
WASHINGTON
American Chemical Society
01.03.2001
Amer Chemical Soc American Society of Pharmacognosy |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Bioassay-guided fractionation of an organic extract of the cell mass from a manipulated plant cell culture of Mirabilis jalapa led to the isolation and subsequent identification of three new phenolic compounds, 1, 2, and 3. The isoflavone 1 and dehydrorotenoid 2 were identified as the principal antifungal principles from this plant cell culture with IC50's of 25 and 48 mug/mL, respectively, against the test organism, Candida albicans DSY1024. The rotenoid 3 was inactive at 200 mug/mL in this assay. |
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| AbstractList | Bioassay-guided fractionation of an organic extract of the cell mass from a manipulated plant cell culture of Mirabilis jalapa led to the isolation and subsequent identification of three new phenolic compounds, 1, 2, and 3. The isoflavone 1 and dehydrorotenoid 2 were identified as the principal antifungal principles from this plant cell culture with IC50's of 25 and 48 mug/mL, respectively, against the test organism, Candida albicans DSY1024. The rotenoid 3 was inactive at 200 mug/mL in this assay. Bioassay-guided fractionation of an organic extract of the cell mass from a manipulated plant cell culture of Mirabilis jalapa led to the isolation and subsequent identification of three new phenolic compounds, 1, 2, and 3. The isoflavone 1 and dehydrorotenoid 2 were identified as the principal antifungal principles from this plant cell culture with IC(50)'s of 25 and 48 microg/mL, respectively, against the test organism, Candida albicans DSY1024. The rotenoid 3 was inactive at 200 microg/mL in this assay. |
| Author | MCALPINE, James ECKER, Dawn M. ROGERS, Bruce YANG, Shu-Wei UBILLAS, Rosa STAFFORD, Angela TALBOT, M. Kelly |
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| Keywords | ROOTS BOERHAAVIA-DIFFUSA L CONSTITUENTS Candida albicans Cell culture Pharmacognosy Tetracyclic compound Nyctaginaceae Oxygen heterocycle Flavonoid In vitro Biological activity Medicinal plant Fungi Antifungal agent Polyphenol Dicotyledones Angiospermae Plant origin Bicyclic compound Isolation Spermatophyta Aromatic compound Fungi Imperfecti Genetically modified organism Thallophyta Structural analysis |
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| References | PIATTELLI, M. (BCI:BCI19664700048907) 1965; 4 GAMBORG OL (WOS:000167725600008.2) 1968; 50 MESHULAM, T (WOS:A1995RW06200043) 1995; 172 WOLLENWEBER E (WOS:000167725600008.9) 1993; 3 LAMI, N (WOS:A1990DN30100020) 1990; 38 TAGUCHI, H (WOS:A1977DJ71500027) 1977; 25 KADOTA, S (WOS:A1989CJ86300009) 1989; 37 STAFFORD AM (WOS:000167725600008.7) 1998 DEWICK PM (WOS:000167725600008.1) 1993 |
| References_xml | – start-page: 117 year: 1993 ident: WOS:000167725600008.1 publication-title: FLAVONOIDS ADV RES 1 contributor: fullname: DEWICK PM – volume: 50 start-page: 155 year: 1968 ident: WOS:000167725600008.2 publication-title: EXP CELL RES contributor: fullname: GAMBORG OL – volume: 25 start-page: 1026 year: 1977 ident: WOS:A1977DJ71500027 article-title: CONSTITUENTS OF CLITORIA-MACROPHYLLA-WALL - CAT, A THAI MEDICINAL PLANT - STRUCTURE OF A NEW ROTENOID, CLITORIACETAL publication-title: CHEMICAL & PHARMACEUTICAL BULLETIN contributor: fullname: TAGUCHI, H – volume: 37 start-page: 3214 year: 1989 ident: WOS:A1989CJ86300009 article-title: CONSTITUENTS OF THE ROOTS OF BOERHAAVIA-DIFFUSA L .1. EXAMINATION OF STEROLS AND STRUCTURES OF NEW ROTENOIDS, BOERAVINONE-A AND BOERAVINONE-B publication-title: CHEMICAL & PHARMACEUTICAL BULLETIN contributor: fullname: KADOTA, S – volume: 4 start-page: 817 year: 1965 ident: BCI:BCI19664700048907 article-title: Pigments of Centro-spermae. V. Betaxanthins from Mirabilis jalapa L publication-title: PHYTOCHEM ISTRY contributor: fullname: PIATTELLI, M. – volume: 38 start-page: 1558 year: 1990 ident: WOS:A1990DN30100020 article-title: CONSTITUENTS OF THE ROOTS OF BOERHAAVIA-DIFFUSA L .2. STRUCTURE AND STEREOCHEMISTRY OF A NEW ROTENOID, BOERAVINONE-C publication-title: CHEMICAL & PHARMACEUTICAL BULLETIN contributor: fullname: LAMI, N – volume: 3 start-page: 119 year: 1993 ident: WOS:000167725600008.9 publication-title: NAT PROD LETT contributor: fullname: WOLLENWEBER E – volume: 172 start-page: 1153 year: 1995 ident: WOS:A1995RW06200043 article-title: A SIMPLIFIED NEW ASSAY FOR ASSESSMENT OF FUNGAL CELL-DAMAGE WITH THE TETRAZOLIUM DYE, (2,3)-BIS-(2-METHOXY-4-NITRO-5-SULFENYL)-(2H)-TETRAZOLIUM-5-CARBOXANILIDE (XTT) publication-title: JOURNAL OF INFECTIOUS DISEASES contributor: fullname: MESHULAM, T – start-page: 53 year: 1998 ident: WOS:000167725600008.7 publication-title: ADV DRUG DISCOVERY T contributor: fullname: STAFFORD AM |
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| SubjectTerms | Antifungal Agents - chemistry Antifungal Agents - isolation & purification Biological and medical sciences Biotechnology Candida albicans - drug effects Cells, Cultured Chemistry, Medicinal Eukaryotic cell cultures Fundamental and applied biological sciences. Psychology General pharmacology Life Sciences & Biomedicine Magnetic Resonance Spectroscopy Magnoliopsida - chemistry Medical sciences Methods. Procedures. Technologies Microbial Sensitivity Tests Miscellaneous Pharmacognosy. Homeopathy. Health food Pharmacology & Pharmacy Pharmacology. Drug treatments Phenols - chemistry Phenols - isolation & purification Plant cells and fungal cells Plant Sciences Science & Technology |
| Title | Three New Phenolic Compounds from a Manipulated Plant Cell Culture, Mirabilis jalapa |
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