Dactylolide, a New Cytotoxic Macrolide from the Vanuatu Sponge Dactylospongia sp

• Published in: European journal of organic chemistry Vol. 2001; no. 4; pp. 775 - 778
• Main Authors: Cutignano, Adele, Bruno, Ines, Bifulco, Giuseppe, Casapullo, Agostino, Debitus, Cécile, Gomez-Paloma, Luigi, Riccio, Raffaele
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag GmbH 01.02.2001; WILEY‐VCH Verlag GmbH; Wiley
• Subjects: Antitumor agents; Chemistry; Chemistry, Organic; Macrolides; Natural products; NMR spectroscopy; Physical Sciences; Science & Technology; Structural elucidation; SWINHOLIDE-A; LATRUNCULIN; natural products; macrolides; TOXINS; SENSITIVITY; structural elucidation; CELL-GROWTH; NMR spectroscopy; antitumor agents; MARINE SPONGE
• ISSN: 1434-193X; 1099-0690
• DOI: 10.1002/1099-0690(200102)2001:4<775::AID-EJOC775>3.0.CO;2-Z

Dactylolide (1), a new cytotoxic 20‐membered macrolide, was isolated from a marine sponge of the genus Dactylospongia collected off the coast of the Vanuatu islands. It co‐occurred with other known bioactive macrolides: latrunculin A (2), laulimalide (3), isolaulimalide (4) and with the anthelminthic mycothiazole (5). The structure of 1, which is a minor metabolite, was elucidated by spectroscopy (mainly by 1D/2D NMR and MS techniques). It showed cytotoxic activity against the L1210 and SK‐OV‐3 tumor cell lines (63% and 40% inhibition at 3.2 μg/mL).