Omeprazole and talampanel as two examples of retrometabolic drug design

The goal of retrometabolic drug design is: 'to design safe, locally active compounds with an improved therapeutic index'. Here we describe two cases from our own practice, talampanel and omeprazole.

Saved in:
Bibliographic Details
Published inPharmazie Vol. 59; no. 5; pp. 365 - 366
Main Authors Andrási, F., Berzsenyi, P., Farkas, L., Kōrösi, J., Hámori, T., Botka, P., Ling, I., Láng, T.
Format Journal Article
LanguageEnglish
Published Germany Govi-Verlag 01.05.2004
Subjects
Anticonvulsants - chemical synthesis
Anticonvulsants - metabolism
Anticonvulsants - pharmacology
Benzodiazepines - chemical synthesis
Benzodiazepines - metabolism
Benzodiazepines - pharmacology
Drug Design
Enzyme Inhibitors - chemical synthesis
Enzyme Inhibitors - metabolism
Enzyme Inhibitors - pharmacology
Indicators and Reagents
Omeprazole - chemical synthesis
Omeprazole - metabolism
Omeprazole - pharmacology
Proton Pump Inhibitors
Structure-Activity Relationship
Online AccessGet full text

Cover

More Information
Summary:The goal of retrometabolic drug design is: 'to design safe, locally active compounds with an improved therapeutic index'. Here we describe two cases from our own practice, talampanel and omeprazole.
Bibliography:0031-7144(20040501)59:5L.365;1-
ISSN:0031-7144