Necrotizing myopathy induced by overexpression of interferon-γ in transgenic mice
A transgenic mouse model has been established in which the cytokine interferon‐γ (IFN‐γ) is overexpressed through the action of the acetylcholine receptor epsilon promoter acting at the neuromuscular junction. While originally developed as a model for the study of the pathogenesis of myasthenia grav...
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Published in | Muscle & nerve Vol. 22; no. 2; pp. 156 - 165 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
New York
John Wiley & Sons, Inc
01.02.1999
Wiley |
Subjects | |
Online Access | Get full text |
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Summary: | A transgenic mouse model has been established in which the cytokine interferon‐γ (IFN‐γ) is overexpressed through the action of the acetylcholine receptor epsilon promoter acting at the neuromuscular junction. While originally developed as a model for the study of the pathogenesis of myasthenia gravis, there are important differences from both human myasthenia gravis and its animal model, experimental autoimmune myasthenia gravis. By 4 months of age there was a well‐established inflammatory, predominantly necrotizing myopathy, with marked dystrophic calcification. Dystrophic and degenerative changes in terminal axons and adjacent Schwann cells were also apparent. The acetylcholine receptor was not the primary target of the inflammatory response, since at 10 weeks of age the receptor content was not decreased and antibodies were not detected bound to the receptor. The IFNγ transgenic mouse model may provide a clinically relevant model of necrotizing myopathy for investigation of the pathological changes associated with, and presumably precipitated by, overexpression of the proinflammatory cytokine interferon‐γ on the neuromuscular junction, intramuscular nerves and myofibers. © 1999 John Wiley & Sons, Inc. Muscle Nerve 22: 156–165, 1999 |
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Bibliography: | istex:937FE75A4E96FFCD2E64225E95FA96FDB9131256 ark:/67375/WNG-WRHHD26G-D ArticleID:MUS3 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0148-639X 1097-4598 |
DOI: | 10.1002/(SICI)1097-4598(199902)22:2<156::AID-MUS3>3.0.CO;2-U |