Synthesis of Novel 1H-Imidazol[1,2-a]Indeno[2,1-e]Pyridine-6(5H)-Ones Derivatives via a One-Pot Four-Component Condensation Reaction

1H‐imidazol[1,2‐a]indeno[2,1‐e]pyridine‐6(5H)‐ones derivatives were synthesized in a one‐pot four‐component condensation of corresponding aldehydes, 1,3‐indandione, diamine, and nitro ketene dithioacetal using KAl(SO4)2·12H2O (alum) as nontoxic, reusable, inexpensive and easily available catalyst in...

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Bibliographic Details
Published inJournal of heterocyclic chemistry Vol. 53; no. 3; pp. 805 - 808
Main Authors Mohammadi, Ali A., Taheri, Salman, Amouzegar, Ali
Format Journal Article
LanguageEnglish
Published HOBOKEN Blackwell Publishing Ltd 01.05.2016
Wiley
Wiley Subscription Services, Inc
Subjects
1-e]pyridine
2-a]indeno
Alum
Chemistry
Chemistry, Organic
imidazol
imidazol[1,2‐a]indeno[2,1‐e]pyridine
Multi component reactions
Physical Sciences
Science & Technology
TOPOISOMERASES-I
BREAST-CANCER
EFFICIENT CATALYST
SOLVENT-FREE CONDITIONS
INHIBITORS
IMIDAZOPYRIDINE
WATER
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Summary:1H‐imidazol[1,2‐a]indeno[2,1‐e]pyridine‐6(5H)‐ones derivatives were synthesized in a one‐pot four‐component condensation of corresponding aldehydes, 1,3‐indandione, diamine, and nitro ketene dithioacetal using KAl(SO4)2·12H2O (alum) as nontoxic, reusable, inexpensive and easily available catalyst in good to excellent yields. This green protocol provides a powerful entry into fused polycyclic structures related to bioactive heterocycles.
Bibliography:ark:/67375/WNG-BF9K2MNL-9
istex:C6C1AF1F8C27611E86210598EBA116228309FA30
ArticleID:JHET2352
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.2352