Sol-gel-derived bioactive glass containing SiO2-MgO-CaO-P2O5 as an antibacterial scaffold

• Published in: Journal of biomedical materials research. Part A Vol. 101A; no. 6; pp. 1582 - 1587
• Main Authors: Imani Fooladi, Abbas Ali, Hosseini, Hamideh Mahmoodzadeh, Hafezi, Forough, Hosseinnejad, Fatemeh, Nourani, Mohammad Reza
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.06.2013; Wiley-Blackwell
• Subjects: aerobic bacteria; Animals; Anti-Bacterial Agents - pharmacology; antibacterial activity; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; bioactive glass; Biological and medical sciences; Cell Survival - drug effects; CHO Cells; Cricetinae; Cricetulus; Escherichia coli - drug effects; Glass - chemistry; Medical sciences; Microbial Sensitivity Tests; Nanoparticles - ultrastructure; nasocomial infection; Pharmacology. Drug treatments; Phase Transition - drug effects; Powders; Pseudomonas aeruginosa - drug effects; sol-gel process; Staining and Labeling; Staphylococcus aureus - drug effects; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Technology. Biomaterials. Equipments; Tissue Scaffolds - chemistry; Trypan Blue - metabolism; X-Ray Diffraction; Biological properties; antibacterial activity; aerobic bacteria; Magnesium oxide; Glass; Scaffold; Silica; Bactericidal effect; Colloidal gel; Infection; bioactive glass; Sol gel process; sol―gel process; Silicon Oxides; Bacteria; Biomaterial; Antibacterial agent; nasocomial infection; Biomedical engineering
• ISSN: 1549-3296; 1552-4965
• DOI: 10.1002/jbm.a.34464

Bioactive glass (BG) composites with a base of SiO2–Na2O–CaO–P2O5 are biocompatible biomaterials. The assessment of their abilities for medical applications has interested researchers. We produced a BG‐containing SiO2–MgO–CaO–P2O5 by the sol–gel method. To determine the antibacterial effects, we analyzed the minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) properties of this product on three microorganisms, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa, known causative agents for biofilm formation on implant surfaces. In addition, we performed the 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide assay to study the cytotoxic effects of our composite on animal cells. Our results demonstrated that our BG product inhibited the growth of bacteria in a concentration‐dependent manner without any cytotoxic effects. Therefore, our BG product can be utilized as an appropriate implant for treating bone and tooth defects. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013.