High-frequency backscatter analysis of human articular cartilage

46 punch biopsies of human cartilage were collected and scanned in time-resolved C-scan mode using a scanning acoustic microscope with a single-element 40-MHz transducer. From these data, spectra were estimated from short time gates at regions with low inclination and averaged with respect to their...

Full description

Saved in:
Bibliographic Details
Published in2013 IEEE International Ultrasonics Symposium (IUS) pp. 1228 - 1231
Main Authors Mannicke, Nils, Schone, Martin, Gottwald, Mathias, Gobel, Felix, Oelze, Michael, Raum, Kay
Format Conference Proceeding
LanguageEnglish
Published IEEE 01.07.2013
Subjects
Acoustics
Backscatter
cartilage
Correlation
degeneration
envelope statistics
Joints
Scattering
Spectral analysis
Transducers
Ultrasonic imaging
Online AccessGet full text

Cover

More Information
Summary:46 punch biopsies of human cartilage were collected and scanned in time-resolved C-scan mode using a scanning acoustic microscope with a single-element 40-MHz transducer. From these data, spectra were estimated from short time gates at regions with low inclination and averaged with respect to their time delay to the tissue surface to account for the curved shape of articular cartilage. The depth-dependent spectral slope and amplitude profiles were used to estimate the maximum values and the depth-dependent slope. The surface reflection was excluded from analysis. In addition, the homodyned k distribution was used to model the signal amplitude of the envelope at tissue depths between 200 and 600 μm. The k and μ parameters were estimated from the envelope data. Kruskal-Wallis analyses of variance were carried out for the acoustic parameters with respect to subscores of the Mankin grading system that are related to cellular and structural abnormalities of the cartilage matrix. The grading was performed on 2D histological cross sections. Additionally the cell number density was assessed.
ISSN:1051-0117
DOI:10.1109/ULTSYM.2013.0314