The effects of probiotics on mental health and hypothalamic-pituitary-adrenal axis: A randomized, double-blind, placebo-controlled trial in petrochemical workers

• Published in: Nutritional neuroscience Vol. 19; no. 9; pp. 387 - 395
• Main Authors: Mohammadi, Ali Akbar, Jazayeri, Shima, Khosravi-Darani, Kianoush, Solati, Zahra, Mohammadpour, Nakisa, Asemi, Zatollah, Adab, Zohre, Djalali, Mahmoud, Tehrani-Doost, Mehdi, Hosseini, Mostafa, Eghtesadi, Shahryar
• Format: Journal Article
• Language: English
• Published: Taylor & Francis 08.11.2016
• Subjects: Hypothalamic-pituitary-adrenal axis; Mental health; Petrochemical workers; Probiotics
• ISSN: 1028-415X; 1476-8305; 1476-8305
• DOI: 10.1179/1476830515Y.0000000023

Objective: The aim of this study was to determine effects of probiotic yogurt and multispecies probiotic capsule supplementation on mental health and hypothalamic-pituitary-adrenal axis in petrochemical workers. Methods: The present randomized double-blind, placebo-controlled trial was conducted on 70 petrochemical workers. Subjects were randomly divided into three groups to receive 100 g/day probiotic yogurt + one placebo capsule (n = 25) or one probiotic capsule daily + 100 g/day conventional yogurt (n = 25) or 100 g/day conventional yogurt + one placebo capsule (n = 20) for 6 weeks. Mental health parameters including general health questionnaire (GHQ) and depression anxiety and stress scale (DASS) scores were measured. Fasting blood samples were obtained at the beginning and 6 weeks after the intervention to quantify hypothalamic-pituitary-adrenal axis. Results: After 6 weeks of intervention, a significant improvement of GHQ was observed in the probiotic yogurt (18.0 ± 1.5 vs. 13.5 ± 1.9, P = 0.007) and in the probiotic capsule group (16.9 ± 1.8 vs. 9.8 ± 1.9, P = 0.001), as well as a significant improvement in DASS scores in the probiotic yogurt (23.3 ± 3.7 vs. 13.0 ± 3.7, P = 0.02) and the probiotic capsule group (18.9 ± 3.2 vs. 9.4 ± 4.0, P = 0.006). However, there was no significant improvement in the conventional yogurt group (P = 0.05 for GHQ and P = 0.08 for DASS). Discussion: The consumption of probiotic yogurt or a multispecies probiotic capsule had beneficial effects on mental health parameters in petrochemical workers.