Synthesis of 2-substituted 2-arylmalonates via tricarbonylchromium complexes

• Published in: Journal für praktische Chemie, Chemiker-Zeitung Vol. 339; no. 3; pp. 261 - 265
• Main Authors: Deutsch, J, Bartoszek, M, Schneider, M, Zabel, Niclas, HJ
• Format: Journal Article
• Language: English
• Published: HEIDELBERG JOHANN AMBROSIUS BARTH VERLAG 01.01.1997
• Subjects: Chemistry; Chemistry, Applied; Chemistry, Multidisciplinary; Physical Sciences; Science & Technology; CARBANIONS; REAGENTS; ARYLATION

Tricarbonylchromium complexes 1 react with monosubstituted malonic acid esters 2 in DMSO at room temperature in the presence of KOtBu to give the complexes 3. After oxidative demetalation, the appropriate aryl derivatives 4 are obtained in moderate to good overall yields. Diastereoselective arylatio...