Synthesis of 2-substituted 2-arylmalonates via tricarbonylchromium complexes
Tricarbonylchromium complexes 1 react with monosubstituted malonic acid esters 2 in DMSO at room temperature in the presence of KOtBu to give the complexes 3. After oxidative demetalation, the appropriate aryl derivatives 4 are obtained in moderate to good overall yields. Diastereoselective arylatio...
Saved in:
Published in | Journal für praktische Chemie, Chemiker-Zeitung Vol. 339; no. 3; pp. 261 - 265 |
---|---|
Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
HEIDELBERG
JOHANN AMBROSIUS BARTH VERLAG
01.01.1997
|
Subjects | |
Online Access | Get more information |
Cover
Loading…
Summary: | Tricarbonylchromium complexes 1 react with monosubstituted malonic acid esters 2 in DMSO at room temperature in the presence of KOtBu to give the complexes 3. After oxidative demetalation, the appropriate aryl derivatives 4 are obtained in moderate to good overall yields. Diastereoselective arylations of chirally modified malonates such as 5a-c were studied. The stereoselectivity was highest for the products 6c/6c' (80:20) with (-)-8-phenylmenthol as alcohol component in the malonate 5. |
---|---|
ISSN: | 0941-1216 |
DOI: | 10.1002/prac.19973390146 |