A short and convenient synthesis and evaluation of the antiinfective properties of indoloquinoline alkaloids: 10H-Indolo[3,2-b]quinoline and 7H-indolo[2,3-c]quinolines

10H-Indolo[3,2-b]quinoline and 7H-indolo[2,3-c]quinoline have been synthesized in two steps using a modified approach to our previous reported method. Starting from commercially available 3-aminoquinoline and phenylboronic acid, the first step involved a copper acetate-catalyzed coupling reaction an...

Full description

Saved in:
Bibliographic Details
Published inJournal of heterocyclic chemistry Vol. 45; no. 2; pp. 507 - 511
Main Authors Etukala, Jagan R., Kumar, E. V. K. Suresh, Ablordeppey, Seth Y.
Format Journal Article
LanguageEnglish
Published HOBOKEN Wiley 01.03.2008
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
CRYPTOLEPINE
IN-VITRO
VIVO
METHYL
ANTIMALARIAL ACTIVITY
ISOCRYPTOLEPINE
CRYPTOSANGUINOLENTINE
NEOCRYPTOLEPINE
CYCLIZATION
Online AccessGet more information

Cover

More Information
Summary:10H-Indolo[3,2-b]quinoline and 7H-indolo[2,3-c]quinoline have been synthesized in two steps using a modified approach to our previous reported method. Starting from commercially available 3-aminoquinoline and phenylboronic acid, the first step involved a copper acetate-catalyzed coupling reaction and the second utilized a palladium acetate-catalyzed intramolecular arylation reaction in the presence of trifluoroacetic acid as solvent. The anti-infective activity of a selected number of the compounds was also evaluated.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.5570450232