Convenient way to 5-Substituted 4-amino-2,3-dihydro-4H-1,2,4-triazole-3-thiones

• Published in: Journal of heterocyclic chemistry Vol. 44; no. 2; pp. 279 - 284
• Main Authors: Smicius, Romualdas, Burbulien, Milda Malvina, Jakubkiene, Virginija, Udrenaite, Emilija, Vainilavicius, Povilas
• Format: Journal Article
• Language: English
• Published: PROVO HETERO CORPORATION 01.03.2007
• Subjects: Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; HETEROCYCLES; DERIVATIVES; ANTIMICROBIAL ACTIVITY; 1,2,4-TRIAZOLE

Various 4-amino-2,3-dihydro-4H-triazoles with aromatic, aliphatic and heterocyclic substituents at the C(5) position were synthesized from corresponding esters and thiocarbohydrazide. This method allows the synthesis these heterocycles in a short time and at reduced expenses.