Environmental factors in the etiology of rhabdomyosarcoma in childhood

In a case-control study of childhood rhabdomyosarcoma (RMS), families of 33 cases and 99 controls were interviewed. A relative risk (RR) of 3.9 was found associated with fathers' (but not mothers') cigarette smoking (P = 0.003). Cases had had fewer immunizations than controls, particularly...

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Published inJNCI : Journal of the National Cancer Institute Vol. 68; no. 1; p. 107
Main Authors Grufferman, S, Wang, H H, DeLong, E R, Kimm, S Y, Delzell, E S, Falletta, J M
Format Journal Article
LanguageEnglish
Published United States 01.01.1982
Subjects
Adolescent
Child
Child, Preschool
Diet
Family
Female
Humans
Infant
Infant, Newborn
Male
Maternal Age
Medical History Taking
North Carolina
Pregnancy
Rhabdomyosarcoma - epidemiology
Rhabdomyosarcoma - etiology
Risk
Smoke
Socioeconomic Factors
North Carolina
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Summary:In a case-control study of childhood rhabdomyosarcoma (RMS), families of 33 cases and 99 controls were interviewed. A relative risk (RR) of 3.9 was found associated with fathers' (but not mothers') cigarette smoking (P = 0.003). Cases had had fewer immunizations than controls, particularly smallpox vaccination (RR = 0.2; P = 0.001), and conversely had more preventable infections. An RR of 3.2 (P = 0.03) was found associated with exposure to chemicals and and RR of 3.7 (P = 0.004) was found associated with diets that included organ meats. Mothers of cases were more likely to be over age 30 years at subject's birth, to have used antibiotics preceding or during pregnancy, and to have had an overdue and/or assisted delivery. Other findings suggest that low socioeconomic status is associated with an increased risk of RMS. These aggregate findings imply that environmental factors may play an important role in the etiology of childhood RMS.
ISSN:0027-8874
DOI:10.1093/jnci/68.1.107