A new regioselective synthesis and bioactivity of 1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one derivatives

A series of new1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one Derivatives 5 has been designed and regioselectively synthesized via a tandem aza-Wittig reaction. The structures of all compounds prepared have been confirmed by H-1 NMR, IR, EI-MS spectroscopy and elemental analyses. The results of preliminary b...

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Bibliographic Details
Published inJournal of heterocyclic chemistry Vol. 41; no. 3; pp. 393 - 397
Main Authors Wang, HQ, Liu, ZJ, Yang, LM, Ding, MW
Format Journal Article
LanguageEnglish
Published PROVO HETERO CORPORATION 01.05.2004
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
FUNGICIDAL ACTIVITIES
ANTIFUNGAL ACTIVITY
PYRAZOLO<3,4-D>PYRIMIDINE DERIVATIVES
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Summary:A series of new1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one Derivatives 5 has been designed and regioselectively synthesized via a tandem aza-Wittig reaction. The structures of all compounds prepared have been confirmed by H-1 NMR, IR, EI-MS spectroscopy and elemental analyses. The results of preliminary bioassay indicate that most compounds 5 possess an inhibition effect against Botrytis cinereapers and Pyricularia oryzae at the concentration of 50 mg/L.
ISSN:0022-152X
DOI:10.1002/jhet.5570410314