Identification and Isolation of a Receptor for N-Methyl Alkylammonium Salts: Molecular Amplification in a Pseudo-peptide Dynamic Combinatorial Library

A cyclic pseudo‐peptide receptor for acetylcholine has been amplified and isolated from a dynamic combinatorial library by virtue of templated stabilization under thermodynamic control (see scheme, TFA=trifluoroacetic acid). This is a demonstration of significant molecular amplification in dynamic s...

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Published inAngewandte Chemie (International ed.) Vol. 40; no. 2; pp. 423 - 428
Main Authors Cousins, Graham R. L., Furlan, Ricardo L. E., Ng, Yiu-Fai, Redman, James E., Sanders, Jeremy K. M.
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag GmbH 19.01.2001
WILEY‐VCH Verlag GmbH
Subjects
combinatorial chemistry
hydrazones
molecular evolution
molecular recognition
peptides
receptors
molecular recognition
peptides
combinatorial chemistry
receptors
molecular evolution
hydrazones
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Summary:A cyclic pseudo‐peptide receptor for acetylcholine has been amplified and isolated from a dynamic combinatorial library by virtue of templated stabilization under thermodynamic control (see scheme, TFA=trifluoroacetic acid). This is a demonstration of significant molecular amplification in dynamic systems to evolve a novel receptor.
Bibliography:istex:737A6C08623612342706863668B42E67B98A34FA
ark:/67375/WNG-7W3JK2TZ-D
ArticleID:ANIE423
This work was supported by the Biotechnology and Biological Sciences Research Council (UK), Engineering and Physical Sciences Research Council (UK), Ethyl Corporation (UK), and Fundacion Antorchas and Consejo Nacional de Investigaciones Cientficas y Tecnicas (Argentina).
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ISSN:1433-7851
1521-3773
DOI:10.1002/1521-3773(20010119)40:2<423::AID-ANIE423>3.0.CO;2-6