Ultrasound stimulation of carotid baroreceptors: Initial canine results

Hypertension affects 1 in 3 American adults and is the single largest contributor to death worldwide. In cardiovascular physiology, the baroreflex or baroreceptors reflex is one of the body's homeostatic mechanisms for maintaining blood pressure. Baroreceptors are pressure-sensitive neurons and...

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Bibliographic Details
Published in2015 IEEE International Ultrasonics Symposium (IUS) pp. 1 - 4
Main Authors Yen, Jesse T., Yu Chen, Partsch, Michael J., Covalin, Alejandro
Format Conference Proceeding
LanguageEnglish
Published IEEE 01.10.2015
Subjects
baroreceptors
Baroreflex
Biomedical monitoring
Blood pressure
carotid
Hypertension
Mercury (metals)
neural
stimulation
Transducers
Ultrasonic imaging
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Summary:Hypertension affects 1 in 3 American adults and is the single largest contributor to death worldwide. In cardiovascular physiology, the baroreflex or baroreceptors reflex is one of the body's homeostatic mechanisms for maintaining blood pressure. Baroreceptors are pressure-sensitive neurons and some baroreceptors are located at the bifurcation of the carotid artery. Previous work has shown extensive results using electrical stimulation of the baroreflex to decrease blood pressure in both canine models and human subjects. Coupled with the ever-increasing literature on ultrasound neural stimulation, an experiment to explore the effect of ultrasound stimulation of the carotid baroreceptors on blood pressure was conducted on two canines. Bilateral non-invasive and invasive stimulation using 2, 1 MHz air-backed, single-element focused transducers were used. Blood pressure, heart rate, and body temperature were continuously monitored and recorded. Blood pressure decreased between 12 and 17 mm Hg compared to manual non-invasive stimulation of 12-16 mm Hg.
DOI:10.1109/ULTSYM.2015.0504