Fabrication of Fe3O4@AMNA-CuBr Nanocomposite as a Highly Efficient and Reusable Heterogenous Catalyst for Synthesis of Highly Substituted Oxazoles

• Published in: Polycyclic aromatic compounds Vol. 44; no. 9; pp. 6335 - 6353
• Main Authors: Mahmood Saeed, Shakir, Al-dolaimy, F., Sadoon, Nasier, Abdul Kadhim Ruhaima, Ali, Abdulrazzaq Mohammed, Bahira, A. Rasen, Fadhil, Hussien Radie Alawady, Ahmed, Alsalamy, Ali H., Mustafa, Adnan M.
• Format: Journal Article
• Language: English
• Published: Philadelphia Taylor & Francis 20.10.2024; Taylor & Francis Ltd
• Subjects: @AMNA-CuBr catalyst; Catalysts; Catalytic activity; Chemical synthesis; ecofriendly system; Fabrication; highly substituted oxazoles; Iron oxides; Nanocomposites; Nanoparticles; Nicotinic acid; Nitriles; organic synthesis; Oxazole; Oxazoles; Substitutes; three-component reaction
• ISSN: 1040-6638; 1563-5333
• DOI: 10.1080/10406638.2023.2276251

Research on synthetic methods for the preparation of oxazoles is an important issue among synthetic chemists because oxazole derivatives are structural subunits of various natural active products and are valuable synthetic and pharmaceutical precursors. In this research work, we constructed CuBr supported on surface of magnetic Fe 3 O 4 nanoparticles modified with 6-(aminomethyl)nicotinic acid [Fe 3 O 4 @AMNA-CuBr nanocomposite] and evaluated its catalytic activity for the preparation of highly substituted oxazoles through one-pot three-component reactions of diphenylacetylene derivatives with aryl nitriles and water in PEG as the solvent. The results shown that the Fe 3 O 4 @AMNA-CuBr catalyst was used 8 times without significant decrease in catalytic activity. XRD and TEM analysis confirmed that the structure and morphology that the Fe 3 O 4 @AMNA-CuBr catalyst did not change after 8 runs.