Interaction between adipoderivated mesenchymal stem cells and PLGA/PIepox scaffold with possible use in tissue engineering: in vitro study

The objective of this work was to evaluate the interaction between human mesenchymal cells adipoderived with PLGA/PIepox scaffold made by the centrifugation technique. The best plating cell density was predicted between 0.32 × 10 5 , 0.65 × 10 5 and 1.3 × 10 5 and the best culture time between 24, 4...

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Bibliographic Details
Published inInternational journal of polymeric materials Vol. 72; no. 14; pp. 1132 - 1141
Main Authors Bortolotto Degregori, Emanuelle, Corbellini Henckes, Nicole Andrea, Franco, Nathalia, Luz, Henrique, Maurmann, Natasha, Viana, Altevir Rossato, Rohden, Francieli, Loureiro dos Santos, Luis Alberto, Cirne Lima, Elizabeth Obino, Terraciano, Paula Barros, Oliveira, Fernanda dos Santos, Contesini, Emerson Antonio
Format Journal Article
LanguageEnglish
Published Philadelphia Taylor & Francis 22.09.2023
Taylor & Francis Ltd
Subjects
Biocompatibility
centrifugal spinning
Density
In vivo methods and tests
poly (isoprene)
poly (lactic-co-glycolic acid)
Scaffolds
Stem cells
Tissue engineering
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Summary:The objective of this work was to evaluate the interaction between human mesenchymal cells adipoderived with PLGA/PIepox scaffold made by the centrifugation technique. The best plating cell density was predicted between 0.32 × 10 5 , 0.65 × 10 5 and 1.3 × 10 5 and the best culture time between 24, 48, 72 h. The metabolic activity of the tested groups was similar to their respective controls, except for the higher density and longer cultivation time, which were metabolically more active. The association between the PLGA/PIepox scaffold and adipoderived mesenchymal cells can be considered for future in vivo studies in tissue engineering.
ISSN:0091-4037
1563-535X
DOI:10.1080/00914037.2022.2090354