Intramolecular Cascade C-S Bond Formation: A Safe and New Strategy for the Synthesis of Riluzole Analogues Catalyzed by K2S2O8

Due to the diverse applications of benzothiazoles as a privileged core in the medical and pharmaceutical industry, a simple and efficient method for synthesizing benzothiazoles via aniline, KSCN, K 2 CO 3 , and K 2 S 2 O 8 is very attractive. In this study, the effective and efficient procedure for...

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Published inPolycyclic aromatic compounds Vol. 43; no. 9; pp. 7970 - 7978
Main Authors Abdelbasset, Walid Kamal, Sultan, Mohammed Q., Alkaim, Ayad F., Abdullaevich Ashurov, Tulkin, Altimari, Usama S., Hussein, Baydaa Abed, Mustafa, Yasser Fakri, Hammid, Ali Thaeer
Format Journal Article
LanguageEnglish
Published Philadelphia Taylor & Francis 21.10.2023
Taylor & Francis Ltd
Subjects
Aniline
benzothiazole
Bromine
C-S bond formation
Chemical synthesis
five-membered heterocycles
Hydrogen peroxide
Iodine
K2S2O8
Oxidants
Oxidizing agents
Pharmaceutical industry
Potassium carbonate
Potassium persulfate
riluzole analogues
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Summary:Due to the diverse applications of benzothiazoles as a privileged core in the medical and pharmaceutical industry, a simple and efficient method for synthesizing benzothiazoles via aniline, KSCN, K 2 CO 3 , and K 2 S 2 O 8 is very attractive. In this study, the effective and efficient procedure for the synthesis of benzothiazoles derivatives was described. This protocol avoids the use of hazard chemical oxidants, such as bromine, thionyl chloride, iodine, and H 2 O 2 , and provides an alternative procedure for synthesizing benzothiazoles. K 2 S 2 O 8 as an oxidant was applied to synthesis of benzothiazoles in good to excellent yields.
ISSN:1040-6638
1563-5333
DOI:10.1080/10406638.2022.2143826