One-pot Mukaiyama-Mannich reaction of aldehydes, amines and silyl enol diazoacetate catalyzed by MgI2 etherate

Three-component Mukaiyama-Mannich reaction of aldehydes, amines, and silyl enol diazoacetoacetate was efficiently carried out to afford δ-amino substituted-α-diazoacetoacetate derivatives catalyzed by 5 mol% of MgI 2 etherate (MgI 2 *(OEt 2 ) n ) under mild and neutral reaction conditions in good to...

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Published inPhosphorus, sulfur, and silicon and the related elements Vol. 194; no. 12; pp. 1176 - 1179
Main Authors Mi, Nengju, Meng, Xiangwei, Pan, Haokun, He, Kailun, Zhang, Xingxian
Format Journal Article
LanguageEnglish
Published ABINGDON Taylor & Francis 02.12.2019
Taylor & Francis Ltd
Subjects
Aldehydes
Amines
Chemistry
Chemistry, Inorganic & Nuclear
Chemistry, Organic
etherate
MgI
Mukaiyama-Mannich reaction
Physical Sciences
Science & Technology
silyl enol diazoacetoacetate
Three-component
DIAZOACETOACETATES
DIELS-ALDER ADDITION
Three-component
Mukaiyama?Mannich reaction
MgI2 etherate
silyl enol diazoacetoacetate
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Summary:Three-component Mukaiyama-Mannich reaction of aldehydes, amines, and silyl enol diazoacetoacetate was efficiently carried out to afford δ-amino substituted-α-diazoacetoacetate derivatives catalyzed by 5 mol% of MgI 2 etherate (MgI 2 *(OEt 2 ) n ) under mild and neutral reaction conditions in good to excellent yields.
ISSN:1042-6507
1563-5325
DOI:10.1080/10426507.2019.1633322