Inhibition of 17α-Hydroxylase/C17,20-Lyase (CYP17) from Rat Testis by Green Tea Catechins and Black Tea Theaflavins

In the course of screening for 17α-hydroxylase/C 17,20 -lyase inhibitors from food ingredients, the methanol soluble fraction of green tea and black tea, which were expected to be rich in catechin and theaflavin content, showed potent inhibitory activity. (−)-Epigallocathechin gallate and theaflavin...

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Published inBioscience, biotechnology, and biochemistry Vol. 71; no. 9; pp. 2325 - 2328
Main Authors KIMURA, Ken-ichi, ITAKURA, Yoshie, GOTO, Reika, TOJIMA, Masato, EGAWA, Nobumi, YOSHIHAMA, Makoto
Format Journal Article
LanguageEnglish
Published Japan Society for Bioscience, Biotechnology, and Agrochemistry 23.09.2007
Subjects
(−)-epigallocathechin gallate
17,20
17α-hydroxylase/C
lyase (CYP17)
prostate cancer
theaflavin 3-O-gallate
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Summary:In the course of screening for 17α-hydroxylase/C 17,20 -lyase inhibitors from food ingredients, the methanol soluble fraction of green tea and black tea, which were expected to be rich in catechin and theaflavin content, showed potent inhibitory activity. (−)-Epigallocathechin gallate and theaflavin 3-O-gallate with a pirogallol moiety significantly inhibited C 17,20 -lyase activity on IC 50 values of 24.5 μM and 11.5 μM respectively. They had potent cytotoxicity against human prostate cancer LNCaP cells (IC 50 =28.1 μM and 37.4 μM).
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.70258