The preparation and characterization of gas bubble containing liposomes

• Published in: Conference proceedings (IEEE Engineering in Medicine and Biology Society. Conf.) Vol. 2005; pp. 3998 - 4001
• Main Authors: Liu, Rui, Wei, Xiaohui, Yao, Yanbin, Chai, Qiliang, Chen, Yue, Xu, Yuhong
• Format: Conference Proceeding Journal Article
• Language: English
• Published: United States IEEE 2005
• Subjects: Biological materials; Biomedical imaging; Biomedical materials; contrast agent; Drugs; gas bubbles; Hospitals; Lipidomics; liposome; Medical diagnostic imaging; Stability; Ultrasonic imaging; ultrasound; Vehicles

Liposomes and lipid nano-particles containing gas bubbles have great potentials to be used as ultrasound contrast agents or as drug and gene delivery vehicles. We developed a method to enable in situ CO 2 gas bubbles formation inside liposomes. The resulted bubbles containing liposomes were shown to...