The preparation and characterization of gas bubble containing liposomes

Liposomes and lipid nano-particles containing gas bubbles have great potentials to be used as ultrasound contrast agents or as drug and gene delivery vehicles. We developed a method to enable in situ CO 2 gas bubbles formation inside liposomes. The resulted bubbles containing liposomes were shown to...

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Published inConference proceedings (IEEE Engineering in Medicine and Biology Society. Conf.) Vol. 2005; pp. 3998 - 4001
Main Authors Liu, Rui, Wei, Xiaohui, Yao, Yanbin, Chai, Qiliang, Chen, Yue, Xu, Yuhong
Format Conference Proceeding Journal Article
LanguageEnglish
Published United States IEEE 2005
Subjects
Biological materials
Biomedical imaging
Biomedical materials
contrast agent
Drugs
gas bubbles
Hospitals
Lipidomics
liposome
Medical diagnostic imaging
Stability
Ultrasonic imaging
ultrasound
Vehicles
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Summary:Liposomes and lipid nano-particles containing gas bubbles have great potentials to be used as ultrasound contrast agents or as drug and gene delivery vehicles. We developed a method to enable in situ CO 2 gas bubbles formation inside liposomes. The resulted bubbles containing liposomes were shown to be able to effectively echo ultrasound. Their acoustic properties were assessed by ultrasound imaging and intensity analysis. Compared to most other echogenic liposome formulations reported, our method is easier, faster, and more economical. It would be useful for many applications with improvements and optimization
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISBN:0780387414
9780780387416
ISSN:1094-687X
1557-170X
DOI:10.1109/IEMBS.2005.1615338