Trisomy 8 in Philadelphia chromosome (Ph1)-negative cells in the course of Ph1-positive chronic myelocytic leukemia

A female patient with chronic myelocytic leukemia (CML) in chronic phase after busulfan and interferon treatment had four different cell lines in her bone marrow. In addition to cells with a normal karyotype there were cells with the Philadelphia chromosome (Ph1), cells with trisomy 8 and Ph1, and c...

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Bibliographic Details
Published inGenes chromosomes & cancer Vol. 4; no. 3; p. 269
Main Authors Casali, M, Truglio, F, Milone, G, Di Raimondo, F, Parrinello, G, Maserati, E, Pasquali, F
Format Journal Article
LanguageEnglish
Published United States 01.04.1992
Subjects
Aged
Busulfan - therapeutic use
Chromosomes, Human, Pair 22
Chromosomes, Human, Pair 8
Chromosomes, Human, Pair 9
Female
Humans
Interferon Type I - therapeutic use
Karyotyping
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics
Mosaicism
Recombinant Proteins
Translocation, Genetic
Trisomy
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Summary:A female patient with chronic myelocytic leukemia (CML) in chronic phase after busulfan and interferon treatment had four different cell lines in her bone marrow. In addition to cells with a normal karyotype there were cells with the Philadelphia chromosome (Ph1), cells with trisomy 8 and Ph1, and cells with trisomy 8 as the sole anomaly.
ISSN:1045-2257
1098-2264
DOI:10.1002/gcc.2870040314