Crystal Structures of Staphylococcus aureus Methionine Aminopeptidase Complexed with Keto Heterocycle and Aminoketone Inhibitors Reveal the Formation of a Tetrahedral Intermediate

• Published in: Journal of medicinal chemistry Vol. 47; no. 6; pp. 1325 - 1328
• Main Authors: DOUANGAMATH, Alice, DALE, Glenn E., D'ARCY, Allan, ALMSTETTER, Michael, ECKL, Robert, FRUTOS-HOENER, Annabelle, HENKEL, Bernd, ILLGEN, Katrin, NERDINGER, Sven, SCHULZ, Henk, MACSWEENEY, Aengus, THORMANN, Michael, TREML, Andreas, PIERAU, Sabine, WADMAN, Sjoerd, OEFNER, Christian
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 11.03.2004
• Subjects: Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Biological and medical sciences; Medical sciences; Pharmacology. Drug treatments; Sulfur nitrogen heterocycle; Enzyme; Nitrogen heterocycle; Aminopeptidases; Thiazole derivatives; Inhibitor enzyme complex; Ketone; Organic sulfide; Pyridine derivatives; Peptidases; Aminoketone; Synthetic product; Bacteria; Hydrolases; Micrococcales; Micrococcaceae; Staphylococcus aureus; Methionyl aminopeptidase; Crystalline structure
• ISSN: 0022-2623; 1520-4804
• DOI: 10.1021/jm034188j