Chemically modifiable fluorinated copolymer nanoparticles for 19F-MRI contrast enhancement

Recently there has been interest in developing imaging contrast media for magnetic resonance imaging (MRI) that contain biologically rare, magnetically active nuclei such as fluorine. In principle, fluorinated contrast agents can be used to generate highly selective 19F magnetic resonance images tha...

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Bibliographic Details
Published inJournal of applied polymer science Vol. 126; no. 4; pp. 1218 - 1227
Main Authors Bailey, Mark M., Kline, Steven R., Anderson, Michael D., Staymates, Jessica L., Berkland, Cory
Format Journal Article
LanguageEnglish
Published Hoboken Wiley Subscription Services, Inc., A Wiley Company 15.11.2012
Wiley
Wiley Subscription Services, Inc
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Summary:Recently there has been interest in developing imaging contrast media for magnetic resonance imaging (MRI) that contain biologically rare, magnetically active nuclei such as fluorine. In principle, fluorinated contrast agents can be used to generate highly selective 19F magnetic resonance images that can be superimposed over complimentary 1H magnetic resonance images to provide an anatomical context for the fluorinated contrast agent. Additionally, nanoparticles can be made to target various pathological sites via active and passive targeting mechanisms. In this study, fluorinated nanoparticles were produced using a free radical polymerization of vinyl formamide monomers with two different fluorinated monomers. The nanoparticles showed a clear, single 19F‐NMR signal. Additionally, surface amide groups were hydrolyzed to primary amines to yield additional surface reactivity. Fluorinated nanoparticles produced using a free‐radial polymerization method yield a new nanoparticle for 19F‐MRI applications with potential for facile functionalization. © 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
Bibliography:American Heart Association
NIH - No. R03 AR054035; No. P20 RR016443
ark:/67375/WNG-NQ2HQBH2-C
ArticleID:APP36889
Madison and Lila Self Graduate Fellowship at The University of Kansas
Coulter Foundation
NSF - No. CHE 0719464; No. DMR-0944772
Higuchi Biosciences Center
istex:8EA30638171FDE29EC07A6D017A094EC4FD63E86
University of Oregon's NSF IGERT Fellowship Program - No. DGE-0549503
ISSN:0021-8995
1097-4628
DOI:10.1002/app.36889