Chemically modifiable fluorinated copolymer nanoparticles for 19F-MRI contrast enhancement

• Published in: Journal of applied polymer science Vol. 126; no. 4; pp. 1218 - 1227
• Main Authors: Bailey, Mark M., Kline, Steven R., Anderson, Michael D., Staymates, Jessica L., Berkland, Cory
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 15.11.2012; Wiley; Wiley Subscription Services, Inc
• Subjects: 19F magnetic resonance imaging; Applied sciences; Biological and medical sciences; Contrast media. Radiopharmaceuticals; Exact sciences and technology; fluorinated polymers; Materials science; Medical sciences; nanoparticles; Organic polymers; Pharmacology. Drug treatments; Physicochemistry of polymers; Polymers; Polymers with particular properties; Preparation, kinetics, thermodynamics, mechanism and catalysts; small-angle neutron scattering (SANS); ultra-small angle neutron scattering (USANS); small-angle neutron scattering (SANS); Vinyl derivative copolymer; Acrylic acid copolymer; Particle size; Fluorine containing copolymer; Molecular structure; Nanoparticle; Fluorine 19; Magnetic resonance contrast agent; Experimental study; Nuclear magnetic resonance imaging; Crosslinked copolymer; Hydrolysis; fluorinated polymers; Alcohol copolymer; Chemical modification; nanoparticles; ultrasmall angle neutron scattering (USANS); Preparation; F magnetic resonance imaging; Acrylate copolymer; Allylic derivative copolymer; Radical copolymerization; Amine copolymer
• ISSN: 0021-8995; 1097-4628
• DOI: 10.1002/app.36889

Recently there has been interest in developing imaging contrast media for magnetic resonance imaging (MRI) that contain biologically rare, magnetically active nuclei such as fluorine. In principle, fluorinated contrast agents can be used to generate highly selective 19F magnetic resonance images that can be superimposed over complimentary 1H magnetic resonance images to provide an anatomical context for the fluorinated contrast agent. Additionally, nanoparticles can be made to target various pathological sites via active and passive targeting mechanisms. In this study, fluorinated nanoparticles were produced using a free radical polymerization of vinyl formamide monomers with two different fluorinated monomers. The nanoparticles showed a clear, single 19F‐NMR signal. Additionally, surface amide groups were hydrolyzed to primary amines to yield additional surface reactivity. Fluorinated nanoparticles produced using a free‐radial polymerization method yield a new nanoparticle for 19F‐MRI applications with potential for facile functionalization. © 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012