Multi-resolution LC-MS images alignment using dynamic time warping and Kullback-Leibler distance

Liquid chromatography mass spectrometry (LC-MS) is widely used in comparing proteomes for disease biomarker discovery. An LC-MS experiment produces a 2-D image, where the mass-to-charge ratio and the chromatographic retention time are the coordinates, and the signal intensities represent the abundan...

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Bibliographic Details
Published in2012 19th IEEE International Conference on Image Processing pp. 1681 - 1684
Main Authors Wu, W. K. H., Chung, A. C. S., Lam, H. H. N.
Format Conference Proceeding
LanguageEnglish
Published IEEE 01.09.2012
Subjects
Chemicals
DTW
Heuristic algorithms
Image registration
Image resolution
KLD
LC-MS
Liquids
Mice
multi-resolution
Synchronization
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Summary:Liquid chromatography mass spectrometry (LC-MS) is widely used in comparing proteomes for disease biomarker discovery. An LC-MS experiment produces a 2-D image, where the mass-to-charge ratio and the chromatographic retention time are the coordinates, and the signal intensities represent the abundance of detected peptides. However, there is always a non-linear retention time difference across replicate LC-MS images due to machine drift, such that synchronization of LC-MS images must be performed prior to any further analysis. In this paper, we propose a multi-resolution image alignment scheme to synchronize LC-MS images. Dynamic Time Warping (DTW) is used to reconcile the time differences among images and Kullback-Leibler distance (KLD) is used as a local distance measure. Our proposed scheme has been validated using two real data sets, and promising results have been obtained.
ISBN:1467325341
9781467325349
ISSN:1522-4880
2381-8549
DOI:10.1109/ICIP.2012.6467201