Characterizing ultrasound-controlled drug release by high-speed fluorescence imaging

Ultrasound contrast agents (UCAs) microbubbles (MBs) can be preloaded with a therapeutic agents to achieve high efficiency for US-triggered drug delivery. Here we use fluorescence labeling as a substitute for theraputic drug, and use ultra high-speed fluorescence imaging for time-resolved observatio...

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Bibliographic Details
Published in2012 IEEE International Ultrasonics Symposium pp. 1 - 4
Main Authors Ying Luan, Gelderblom, Erik, Lajoinie, Guillaume, Skachkov, Ilya, Dewitte, Heleen, Geers, Bart, Lentacker, Ine, van der Steen, Ton, Versluis, Michel, de Jong, Nico
Format Conference Proceeding
LanguageEnglish
Published IEEE 01.10.2012
Subjects
Acoustics
controlled release
Drug delivery
Drugs
Fluorescence
fluorescence labeling
high-speed fluorescence imaging
Lipidomics
Materials
release dynamics
Ultrasonic imaging
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Summary:Ultrasound contrast agents (UCAs) microbubbles (MBs) can be preloaded with a therapeutic agents to achieve high efficiency for US-triggered drug delivery. Here we use fluorescence labeling as a substitute for theraputic drug, and use ultra high-speed fluorescence imaging for time-resolved observation of the drug release. Two configurations of drug delivery vehicles were investigated - I) lipid-shelled (unloaded) MBs and II) liposome-loaded (loaded) MBs. Different release phenomena were observed. The dynamics of release was found to be strongly dependent on ultrasonic parameters and on the MB's shell properties. MBs shrinkage following US exposure was analyzed and it indicated close correlation with the fluorescence release. This study provides valuable insights into the drug release mechanisms for ultrasound-controlled drug delivery.
ISBN:9781467345613
146734561X
ISSN:1051-0117
DOI:10.1109/ULTSYM.2012.0510