Non-viral Charge Reversal Vectors for pDNA Delivery

A synthetic vector that transform from a cationic to an anionic lipid intracellularly is described. This charge-reversal lipid was synthesized and characterized, including the supramolecular complex it forms with DNA. Enhanced gene transfection was observed using this synthetic vector compared to cu...

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Published in2006 International Conference of the IEEE Engineering in Medicine and Biology Society Vol. 2006; pp. 4347 - 4349
Main Authors Prata, C.A.H., Yougen Li, Luo, D., McIntosh, T.J., Grinstaff, M.W.
Format Conference Proceeding Journal Article
LanguageEnglish
Published United States IEEE 2006
Subjects
Animals
Anions - chemistry
Biomedical engineering
Chemistry
CHO Cells
Cities and towns
Cricetinae
Cricetulus
Degradation
Design for experiments
DNA
DNA - chemistry
Engineering in medicine and biology
Gene Transfer Techniques
Genetic Vectors
Humans
K562 Cells
Light
Lipidomics
Lipids - chemistry
Microscopy, Electron, Transmission
Scattering, Radiation
Temperature
USA Councils
X-Ray Diffraction
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Summary:A synthetic vector that transform from a cationic to an anionic lipid intracellularly is described. This charge-reversal lipid was synthesized and characterized, including the supramolecular complex it forms with DNA. Enhanced gene transfection was observed using this synthetic vector compared to current cationic lipids
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISBN:9781424400324
1424400325
ISSN:1557-170X
DOI:10.1109/IEMBS.2006.260181