Investigation of N-methyl-D-aspartate induced mechanical behavior of neuroblastoma cells using atomic force microscopy

Physiological conditions of biological samples are regulated by many different parameters including mechanical and biochemical factors etc. Single-cell studies of these parameters are challenging by using conventional bioanalysis methods. However, with the recent advancement in nanotechnology, singl...

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Published in2013 13th IEEE International Conference on Nanotechnology (IEEE-NANO 2013) pp. 329 - 332
Main Authors Yuqiang Fang, Lai, King W. C., Iu, Catherine Y. Y., Lui, Cathy N. P., Fung, Carmen K. M., Hung-Wing Li, Yung, Ken K. L., Ning Xi
Format Conference Proceeding Journal Article
LanguageEnglish
Published IEEE 01.08.2013
Subjects
Accessibility
Atomic force microscopy
Biochemistry
Cells (biology)
Conferences
Force
Imaging
Mechanical properties
Nanotechnology
Neurons
Probes
Quantitative analysis
Real time
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Summary:Physiological conditions of biological samples are regulated by many different parameters including mechanical and biochemical factors etc. Single-cell studies of these parameters are challenging by using conventional bioanalysis methods. However, with the recent advancement in nanotechnology, single-molecule and single-cell analysis is much more accessible. Understanding the changes of neuroblastoma cells in different mechanisms is critical for fundamental research in neurosciences. Here, we investigate the mechanical behavior of SH-SY5Y cells using atomic force microscopy. Topographic imaging of the cells and real-time quantitative analysis of their mechanical properties will be presented in the paper.
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ISSN:1944-9399
1944-9380
DOI:10.1109/NANO.2013.6720884