Mathematical Modeling of Phagocyte Chemotaxis toward and Adherence to Biomaterial Implants

Medical implanted devices usually prompt foreign body reactions that lead to the formation of fibrotic capsule surrounding the implanted devices. Cascade phagocyte responses, such as phagocyte chemotaxis and phagocyte adherence, are believed important in pathogenesis of fibrotic responses. Therefore...

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Bibliographic Details
Published in2007 IEEE International Conference on Bioinformatics and Biomedicine (BIBM 2007) pp. 302 - 307
Main Authors Jiaxing Xue, Jean Gao, Liping Tang
Format Conference Proceeding
LanguageEnglish
Published IEEE 01.01.2007
Subjects
Biological system modeling
Biological systems
Communication system traffic control
Computer simulation
Control theory
Design for experiments
Implants
Mathematical model
Stability
USA Councils
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Summary:Medical implanted devices usually prompt foreign body reactions that lead to the formation of fibrotic capsule surrounding the implanted devices. Cascade phagocyte responses, such as phagocyte chemotaxis and phagocyte adherence, are believed important in pathogenesis of fibrotic responses. Therefore, in-depth understanding of phagocyte chemotaxis and adherence processes is important to successfully reduce the fibrotic responses to improve the stability and functionality of implanted medical devices. This paper hypothesizes the molecular mechanisms governing phagocyte chemotaxis and adherence. To support our hypotheses and to provide the prediction of un-measured dynamic features in phagocyte chemotaxis and adherence processes, mathematical models based on system and control theory are built. To maximize the prediction ability and to guide future experimental design, external controls are provided by the mathematical model. The effectiveness of the mathematical model is demonstrated by computer simulation.
ISBN:0769530311
9780769530314
DOI:10.1109/BIBM.2007.38