NCCD-RxNorm: Linking Chinese Clinical Drugs to International Drug Vocabulary

Objective: Expanding the clinical research network from China to the international community will greatly facilitate the collaborative efforts to conquer emerging pandemics globally. This study aims to link clinical drugs in China with those in USA and beyond, by mapping concepts of clinical drugs i...

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Bibliographic Details
Published in2020 IEEE International Conference on Bioinformatics and Biomedicine (BIBM) pp. 1752 - 1756
Main Authors Zhang, Yaoyun, Li, Jing, Zandt, Mui Van
Format Conference Proceeding
LanguageEnglish
Published IEEE 16.12.2020
Subjects
Chemicals
Chinese clinical drugs
Drug knowledge base
Drug normalization
Drugs
International drug vocabulary
Manuals
RxNorm Extention
Semantics
Sociology
Statistics
Vocabulary
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Summary:Objective: Expanding the clinical research network from China to the international community will greatly facilitate the collaborative efforts to conquer emerging pandemics globally. This study aims to link clinical drugs in China with those in USA and beyond, by mapping concepts of clinical drugs in a Normalized Chinese Clinical Drug (NCCD) knowledge base with RxNorm and the international RxNorm Extension in the OHDSI research network. Methods: At this initial stage, we mainly focused on chemical drugs with a single active ingredient. A hybrid approach combining automated natural language processing technologies and manual review by domain experts was proposed, to normalization of drug names at different specification levels. The statistics of the mapping results, as well as the validation results using top 1000 frequent drugs in clinical settings of China. Results: 2,247 (25.39%) and 588 (6.64%) semantic clinical drugs in NCCD can be mapped to RxNorm and RxNorm Extension, respectively. Moreover, among the top 1000 most frequent clinical drugs in China, 99.6% of chemical drugs can be mapped to RxNorm/Extension at the ingredient level. This high coverage indicates that mapping Chinese chemical drugs to RxNorm/Extension can effectively support downstream clinical research and operations in the near future. Conclusion: The mapping between NCCD to RxNorm/Extension serves as a promising channel to promote transnational clinical research. The mapping terminologies are publicly accessible through OHDSI Athens. (athena.ohdsi. org/)
DOI:10.1109/BIBM49941.2020.9313599