SARS-CoV-2 variant strains and viral phylodynamics of ORF1a-1b genetic aspects in South America

Bioinformatics tools for online sequence analysis of variants have been used worldwide for the phylogenetic approach of SARS-Cov-2 and their variants. The purpose of this work is to contribute to the settlement of the SARS-CoV-2 genetic of the South America pandemic, presenting the ORF1a-1b evaluati...

Full description

Saved in:
Bibliographic Details
Published in2021 International Conference on Computational Science and Computational Intelligence (CSCI) pp. 330 - 336
Main Authors Pontes dos Santos, Luiz Henrique, Cavalcante Ribeiro, Jannison Karlly, Alves, Juliana Osorio, Izabel Florindo Guedes, Maria, da Silva Felipe, Stela Mirla, Martins de Freitas, Raquel, Soares, Paula Matias, Lima da Silva, Claudio Gleidiston, Santos, Cristina Pacheco, Viana Pereira, Eric Petterson, Araujo, Valdevane Rocha, Marilande Ceccatto, Vania
Format Conference Proceeding
LanguageEnglish
Published IEEE 01.12.2021
Subjects
bioinformatics tools
Coronaviruses
in silico
Pandemics
phylogenetic tree
Scientific computing
Sequences
Sociology
South America
viral sequence depositories
Visualization
Online AccessGet full text

Cover

More Information
Summary:Bioinformatics tools for online sequence analysis of variants have been used worldwide for the phylogenetic approach of SARS-Cov-2 and their variants. The purpose of this work is to contribute to the settlement of the SARS-CoV-2 genetic of the South America pandemic, presenting the ORF1a-1b evaluation. We proposed and reviewed two online bioinformatics pipelines for viral phylodynamic and phylogeographic analysis with an interactive visualization platform. The phylodynamics evaluation of South America shows a strong viral capacity to evoke immunity and an impressive multiplicity of variants in rapid expansion with mutations of potential importance, including ORF 1a-1b. They showed stately vital for infection and lethality, spreading and raising your frequency in South America from 1% to 20-30% in one year of pandemic occurrence.
DOI:10.1109/CSCI54926.2021.00034